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Treatment
Polynucleotides
Your skin cells can regenerate. They just need the right impulse.
Duration
6-12 months
Results visible
After 2-4 weeks
Maintenance
2-4 sessions, then every 6 months
Price
from 399 EUR
Medically reviewed by
Aesthetic Medicine Physician · Last reviewed: May 2026
Polynucleotides represent a paradigm shift in aesthetic medicine: we add no volume — we can send a message to your cells. These DNA fragments are biological translators that can give your connective tissue precursor cells the impulse for self-renewal. At minimal med, we use polynucleotides to support the regenerative capacity of your own tissue — the skin can regenerate because we can initiate its self-healing processes, not because we add something. To weigh polynucleotides against Profhilo, the article Polynucleotides vs. Profhilo offers a direct comparison. A broader perspective is in the article Regenerative Medicine: The Future of Skin Rejuvenation.
Your Benefits
- Support of the body's own regeneration processes
- Stimulation of connective tissue precursor cells and collagen synthesis
- Can improve microcirculation and tissue quality
- Can provide anti-inflammatory and antioxidant support
- Natural glow without volume change
- Ideal synergy with Profhilo and skinboosters
The Treatment Process
1
Skin analysis: I assess your skin condition and identify problem areas.
2
Preparation: Cleansing and numbing cream if needed.
3
Injection: The product is injected into the middle layer of the skin.
4
Aftercare: Soothing care and sun protection.
5
Follow-up treatment: 2-4 sessions at 2-4 week intervals recommended.
The Biology of Cell Dialogue
What polynucleotides achieve at the molecular level: stimulation of connective tissue precursor cells, cell proliferation, antioxidation. Why DNA fragments (from salmon or trout DNA) are biocompatible and safe. The paradigm shift: from "correcting" to "communicating."
Indications and Protocols
Skin ageing, acne scars, dark circles, hair loss. The typical 3-4 session protocol. Why polynucleotides are the ideal foundation for other regenerative treatments — they prepare the tissue ecosystem.
Building Without Filler
If you follow the online trends, you can hardly avoid polynucleotides — and rightly so. Instead of filling, they give the body a stimulus for regeneration. Building without filler.
Frequently Asked Questions
What exactly are polynucleotides?
Polynucleotides are short DNA chains obtained from salmon or trout sperm. They are highly biocompatible and stimulate the skin's natural regeneration processes.
How do PN differ from hyaluronic acid?
Hyaluronic acid primarily binds moisture. Polynucleotides work at the cellular level — they stimulate connective tissue precursor cells, promote collagen production, and have antioxidant properties. Both complement each other well.
Can PN be used under the eyes?
Yes, that is one of the great advantages! The eye area is too sensitive for many fillers, but PN are very well tolerated there and effective for dark circles and fine wrinkles.
Are there allergic reactions?
PN are very well tolerated because the DNA structure is similar in all vertebrates. Allergic reactions are extremely rare. Caution is advised with fish allergies. For a detailed safety comparison with exosomes, see Polynucleotides vs Exosomes: Safety Profile 2026.
How many treatments do I need?
For optimal results, I recommend 2-4 sessions at 2-4 week intervals. Then maintenance treatments every 6-12 months.
What do polynucleotides cost?
A session starts from 399 EUR. When booking a series, we offer package prices.
Interested in Polynucleotides?
In a personal consultation, we discuss your wishes and find the optimal treatment for you.
Book a consultationScientific Evidence
- [1] Cavallini M et al.. Polynucleotides in Skin Rejuvenation: A Systematic Review. J Cosmet Dermatol (2024).
- [2] Kim JY et al.. Polydeoxyribonucleotide for Skin Rejuvenation: A Review. Arch Dermatol Res (2023).
Linked studies serve as scientific context and do not constitute treatment guarantees.
